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Dr. Alison Holloway

Tung EWY, A Kawata, M Rigde, WJ Bowers, D Caldwell, AC Holloway, B Robaire, BF Hales and MG Wade.  2017. Gestational and lactational exposure to an environmentally-relevant mixture of brominated flame retardants: Effects on neurodevelopment and metabolism. Birth Defects Res 109: 497-512.

Barra NG, M Lisyansky, TA VanDuzer, S Raha, AC Holloway and DB Hardy.  Maternal nicotine exposure leads to decreased cardiac protein disulfide isomerase and mitochondrial function in male rat offspring.  J Appl Tox (JAT-17-0143 Accepted in press).

De Long NE, DB Hardy, N Ma and AC Holloway. Increased incidence of non-alcoholic fatty liver disease in male rat offspring exposed to fluoxetine during fetal and neonatal life involves the NLRP3 inflammasome and augmented de novo hepatic lipogenesis. J Appl Tox (JAT-17-0201 Accepted in press).

De Long, N.E. and Holloway, A.C., 2017. Early-life chemical exposures and risk of metabolic syndrome. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 10, p.101.

Auerbach, S., Filer, D., Reif, D., Walker, V., Holloway, A.C., Schlezinger, J., Srinivasan, S., Svoboda, D., Judson, R., Bucher, J.R. and Thayer, K.A., 2016. Prioritizing environmental chemicals for obesity and diabetes outcomes research: a screening approach using ToxCast™ high-throughput data. Environmental health perspectives, 124(8), p.1141.

Reynolds, J.N., Dobson, C.C., Brien, D.C., Holloway, A.C. and Brien, J.F., 2016, June. Prenatal alcohol exposure increases adiposity, disrupts pancreatic morphology and alters expression of insulin signaling molecules in the guinea pig.  Alcoholism - Clinical and Experimental Research (Vol. 40, pp. 310A-310A). 

Sanches, J.R., França, L.M., Chagas, V.T., Gaspar, R.S., dos Santos, K.A., Gonçalves, L.M., Sloboda, D.M., Holloway, A.C., Dutra, R.P., Carneiro, E.M. and Cappelli, A.P.G., 2016. Polyphenol-rich extract of Syzygium cumini leaf dually improves peripheral insulin sensitivity and pancreatic islet function in monosodium l-glutamate-induced obese rats. Frontiers in pharmacology, 7

Thomson, E.M., Pal, S., Guénette, J., Wade, M.G., Atlas, E., Holloway, A.C., Williams, A. and Vincent, R., 2016. Ozone inhalation provokes glucocorticoid-dependent and-independent effects on inflammatory and metabolic pathways. Toxicological Sciences, 152(1), pp.17-28.

Wong, M.K., Holloway, A.C. and Hardy, D.B., 2016. Nicotine Directly Induces Endoplasmic Reticulum Stress Response in Rat Placental Trophoblast Giant Cells. Toxicological Sciences, p.kfw019.

Morgan RL, KA Thayer, L Bero, N Bruce, Y Falck-Ytter, D Ghersi, G Guyatt, C Hooijmans, M Langendam, D Mandrioli, RA Mustafa, EA Rehfuess , AA Rooney, B Shea, EK Silbergeld, P Sutton, MS Wolfe, TJ Woodruff, JH Verbeek, AC Holloway , N Santesso and HJ Schünemann. 2016. GRADE: Assessing the quality of evidence in environmental and occupational health. Environ Int 92-93: 611-616.

Akioyamen, L.E., Minhas, H., Holloway, A.C., Taylor, V.H., Akioyamen, N.O. and Sherifali, D., 2016. Effects of depression pharmacotherapy in fertility treatment on conception, birth, and neonatal health: A systematic review. Journal of psychosomatic research, 84, pp.69-80.

Simioni, J., Hutton, E.K., Gunn, E., Holloway, A.C., Stearns, J.C., McDonald, H., Mousseau, A., Schertzer, J.D., Ratcliffe, E.M., Thabane, L. and Surette, M.G., 2016. A comparison of intestinal microbiota in a population of low-risk infants exposed and not exposed to intrapartum antibiotics: The Baby & Microbiota of the Intestine cohort study protocol. BMC pediatrics, 16(1), p.183.

Chaiton, M. and Holloway, A., 2016. Population attributable risk of smoking during pregnancy on obesity in offspring. Can J Public Health, 107(3), p.336.

Avila, C., Holloway, A.C., Hahn, M.K., Morrison, K.M., Restivo, M., Anglin, R. and Taylor, V.H., 2015. An overview of links between obesity and mental health. Current obesity reports, 4(3), pp.303-310.

Pereira, R.D., De Long, N.E., Wang, R.C., Yazdi, F.T., Holloway, A.C. and Raha, S., 2015. Angiogenesis in the placenta: the role of reactive oxygen species signaling. BioMed research international, article 814543.

Nicole, E., Barry, E.J., Pinelli, C., Wood, G.A., Hardy, D.B., Morrison, K.M., Taylor, V.H., Gerstein, H.C. and Holloway, A.C., 2015. Antenatal exposure to the selective serotonin reuptake inhibitor fluoxetine leads to postnatal metabolic and endocrine changes associated with type 2 diabetes in Wistar rats. Toxicology and applied pharmacology, 285(1), pp.32-40.

De Long, N.E., Gutgesell, M.K., Petrik, J.J. and Holloway, A.C., 2015. Fetal Exposure to Sertraline Hydrochloride Impairs Pancreatic β-Cell Development. Endocrinology, 156(6), pp.1952-1957.

Wong, M.K., Barra, N.G., Alfaidy, N., Hardy, D.B. and Holloway, A.C., 2015. Adverse effects of perinatal nicotine exposure on reproductive outcomes. Reproduction, 150(6), pp.R185-R193.

De Long NE, RA Stepita, VH Taylor and AC Holloway.  2015. Major depressive disorder and diabetes: does serotonin bridge the gap?  Curr Diabetes Rev 11: 71-78.

Moore, C.J., DeLong, N.E., Chan, K.A., Holloway, A.C. and Petrik, J.J., 2015. Perinatal administration of a selective serotonin reuptake inhibitor induces impairments in reproductive function and follicular dynamics in female rat offspring. Reproductive sciences, pp.1-15.

Tessier, D.R., Raha, S., Holloway, A.C., Yockell-Lelièvre, J., Tayade, C. and Gruslin, A., 2015. Characterization of immune cells and cytokine localization in the rat utero-placental unit mid-to late gestation. Journal of reproductive immunology, 110, pp.89-101.

Moore, C.J., DeLong, N.E., Chan, K.A., Holloway, A.C. and Sloboda, D.M., 2014, March. Perinatal Exposure to a Selective Serotonin Reuptake Inhibitor (SSRI) Induces Changes in Reproductive Function in Female Rat Offspring. Reproductive Sciences (Vol. 21, No. 3, pp. 271A-271A). ​​

Nguyen, P.V., Ashkar, A.A., Holloway, A.C. and Kaushic, C., 2014. Increased susceptibility to primary Hsv-2 infection during early gestation leads to implantation failure and adverse pregnancy outcome in a mouse model. American Journal of Reproductive Immunology, 71, pp.71-72.

De Long, N.E., Barra, N.G., Hardy, D.B. and Holloway, A.C., 2014. Is it safe to use smoking cessation therapeutics during pregnancy? Expert opinion on drug safety, 13(12), pp.1721-1731.

Holloway, A.C., Salomon, A., Soares, M.J., Garnier, V., Raha, S., Sergent, F., Nicholson, C.J., Feige, J.J., Benharouga, M. and Alfaidy, N., 2014. Characterization of the adverse effects of nicotine on placental development: in vivo and in vitro studies. American Journal of Physiology-Endocrinology and Metabolism, 306(4), pp.E443-E456.

De Long, N.E., Barry, E., Pinelli, C., Wood, G., Hardy, D.B., Morrison, K.M., Taylor, V.H., Gerstein, H.C. and Holloway, A.C., 2014. Perinatal Exposure to the Selective Serotonin Reuptake Inhibitor Fluoxetine Results in Hepatic Lipid Accumulation and Inflammation. In Obesity and Inflammation (pp. SUN-0910). Endocrine Society.

Salman, S., Holloway, A.C. and Nurse, C.A., 2014. Chronic opioids regulate KATP channel subunit Kir6. 2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A. American Journal of Physiology-Cell Physiology, 307(3), pp.C266-C277.

Barra, N.G., Palanivel, R., Denou, E., Chew, M.V., Gillgrass, A., Walker, T.D., Kong, J., Richards, C.D., Jordana, M., Collins, S.M. and Trigatti, B.L., 2014. Interleukin-15 modulates adipose tissue by altering mitochondrial mass and activity. PloS one, 9(12), p.e114799.

Hayes, E.K., Tessier, D.R., Percival, M.E., Holloway, A.C., Petrik, J.J., Gruslin, A. and Raha, S., 2014. Trophoblast invasion and blood vessel remodeling are altered in a rat model of lifelong maternal obesity. Reproductive Sciences, 21(5), pp.648-657.

Tessier, D.R., Yockell-Lelievre, J., Raha, S., Holloway, A. and Gruslin, A., 2014, March. Maternal Obesity Influences Uterine Immune Response and Trophoblast Invasion. Reproductive Sciences (Vol. 21, No. 3, pp. 380A-380A). 

 McNulty, J., Keskar, K., Crankshaw, D.J. and Holloway, A.C., 2014. Discovery of a new class of cinnamyl-triazole as potent and selective inhibitors of aromatase (cytochrome P450 19A1). Bioorganic & medicinal chemistry letters, 24(18), pp.4586-4589.

De Long, N.E., Hyslop, J.R., Raha, S., Hardy, D.B. and Holloway, A.C., 2014. Fluoxetine-induced pancreatic beta cell dysfunction: New insight into the benefits of folic acid in the treatment of depression. Journal of affective disorders, 166, pp.6-13.

Dobson, C.C., Thevasundaram, K., Mongillo, D.L., Winterborn, A., Holloway, A.C., Brien, J.F. and Reynolds, J.N., 2014. Chronic prenatal ethanol exposure alters expression of central and peripheral insulin signaling molecules in adult guinea pig offspring. Alcohol, 48(7), pp.687-693.

Dobson, C.C., Thevasundaram, K., Mongillo, D., Winterborn, A., Holloway, A.C., Brien, J.F. and Reynolds, J.N., 2014. Chronic Prenatal Ethanol Exposure Alters Insulin And Insulin-like Growth Factor Signaling In The Adult Guinea Pig. Alcoholism: Clinical & Experimental Research, 38, p.260A.

Ma, N., Nicholson, C.J., Wong, M., Holloway, A.C. and Hardy, D.B., 2014. Fetal and neonatal exposure to nicotine leads to augmented hepatic and circulating triglycerides in adult male offspring due to increased expression of fatty acid synthase. Toxicology and applied pharmacology, 275(1), pp.1-11.

McNulty, J., Nielsen, A.J., Brown, C.E., DiFrancesco, B.R., Vurgun, N., Nair, J.J., Crankshaw, D.J. and Holloway, A.C., 2013. Investigation of aryl halides as ketone bioisosteres: Refinement of potent and selective inhibitors of human cytochrome P450 19A1 (aromatase). Bioorganic & medicinal chemistry letters, 23(22), pp.6060-6063.

Crankshaw, D.J., Pistilli, M.J., O’Brien, Y.M., Sweeney, E.M., Dockery, P., Holloway, A.C. and Morrison, J.J., 2013. The effects of extracellular calcium-sensing receptor ligands on the contractility of pregnant human myometrium in vitro. Reproductive sciences, p.1933719112468949.

De Long, N., Hyslop, J.R., Nicholson, C.J., Morrison, K.M., Gerstein, H.C. and Holloway, A.C., 2013. Postnatal metabolic and reproductive consequences of fetal and neonatal exposure to the smoking cessation drug bupropion. Reproductive Sciences, 20(10), pp.1156-1161.

Holloway, A., Salomon, A., Raha, S., Sergent, M.F., Nicholson, C.J., Feige, J.J., Benharouga, M. and Alfaidy, N., 2013. Effet de l’exposition à la nicotine sur le développement placentaire: étude in vivo et in vitro. Annales d'Endocrinologie (Vol. 74, No. 4, pp. 262-263). 

Behl, M., Rao, D., Aagaard, K., Davidson, T.L., Levin, E.D., Slotkin, T.A., Srinivasan, S., Wallinga, D., White, M.F., Walker, V.R. and Thayer, K.A., 2013. Evaluation of the association between maternal smoking, childhood obesity, and metabolic disorders: a national toxicology program workshop review. Environmental Health Perspectives (Online), 121(2), p.170.

Badv, M., Hosseini, Z., De Long, N., Holloway, A. and Wohl, G., 2013, February. Fetal Exposure to Selective Serotonin Reuptake Inhibitors has Long-Term Adverse Effect on Bone Properties in Rats. Journal of Bone and Mineral Research (Vol. 28).

Ma, N.L., Wong, M., Nicholson, C.J., Holloway, A.C. and Hardy, D.B., 2013, March. Maternal Nicotine Exposure Leads to Elevated Triglycerides in Adult Rat Offspring: The Role of the Liver X Receptor (LXR alpha). Reproductive Sciences (Vol. 20, No. S 3, pp. 279A-279A). 

Barra, N.G., Chew, M.V., Holloway, A.C. and Ashkar, A.A., 2012. Interleukin‐15 treatment improves glucose homeostasis and insulin sensitivity in obese mice. Diabetes, Obesity and Metabolism, 14(2), pp.190-193.

Lopez-Yarto, M., Ruiz-Mirazo, E., Holloway, A.C., Taylor, V.H. and McDonald, S.D., 2012. Do psychiatric medications, especially antidepressants, adversely impact maternal metabolic outcomes? Journal of affective disorders, 141(2), pp.120-129.

Dobson, C.C., Mongillo, D.L., Brien, D.C., Stepita, R., Poklewska-Koziell, M., Winterborn, A., Holloway, A.C., Brien, J.F. and Reynolds, J.N., 2012. Chronic prenatal ethanol exposure increases adiposity and disrupts pancreatic morphology in adult guinea pig offspring. Nutrition & diabetes, 2(12), p.e57.

Hayes, E.K., Lechowicz, A., Petrik, J.J., Storozhuk, Y., Paez-Parent, S., Dai, Q., Samjoo, I.A., Mansell, M., Gruslin, A., Holloway, A.C. and Raha, S., 2012. Adverse fetal and neonatal outcomes associated with a life-long high fat diet: role of altered development of the placental vasculature. PLoS One, 7(3), p.e33370.

Woynillowicz, A.K., Raha, S., Nicholson, C.J. and Holloway, A.C., 2012. The effect of smoking cessation pharmacotherapies on pancreatic beta cell function. Toxicology and applied pharmacology, 265(1), pp.122-127.

Bruin, J.E., Woynillowicz, A.K., Hettinga, B.P., Tarnopolsky, M.A., Morrison, K.M., Gerstein, H.C. and Holloway, A.C., 2012. Maternal antioxidants prevent β‐cell apoptosis and promote formation of dual hormone‐expressing endocrine cells in male offspring following fetal and neonatal nicotine exposure. Journal of diabetes, 4(3), pp.297-306.

Pistilli, M.J., Petrik, J.J., Holloway, A.C. and Crankshaw, D.J., 2012. Immunohistochemical and functional studies on calcium‐sensing receptors in rat uterine smooth muscle. Clinical and Experimental Pharmacology and Physiology, 39(1), pp.37-42.

De Long, N.E., Stepita, R.A., Taylor, V.H., Morrison, K.M., Gerstein, H.C. and Holloway, A.C., 2012, March. Fetal Exposure to the Selective Serotonin Reuptake Inhibitor Sertraline Results in Impaired Fetal Growth and Pancreatic Development in Wistar Rats. Reproductive Sciences (Vol. 19, No. S 3, pp. 119A-119A).

McNulty, J., Nair, J.J., Vurgun, N., DiFrancesco, B.R., Brown, C.E., Tsoi, B., Crankshaw, D.J. and Holloway, A.C., 2012. Discovery of a novel class of aldol-derived 1, 2, 3-triazoles: Potent and selective inhibitors of human cytochrome P450 19A1 (aromatase). Bioorganic & medicinal chemistry letters, 22(1), pp.718-722.

Raha, S., Taylor, V.H. and Holloway, A.C., 2012. Effect of atypical antipsychotics on fetal growth: is the placenta involved? Journal of pregnancy, 2012.


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